Arizona Cardinals (1-4) at Los Angeles Rams (2-3)
Sunday, 4:05 p.m. ET
FanDuel odds: Rams -12.5. Total: 51.5.
Series Rewind: The Rams have won three consecutive games over Arizona. Matthew Stafford threw four TD passes in the 37-20 victory to end the 2025 regular season.
Another hard-luck defeat, 37-34 to the Buffalo Bills on Monday night, sends the Rams into Week 6. They’ve played well in the second half of late — LA scored 14 fourth-quarter points to defeat the Philadelphia Eagles 24-20 in Week 4 and forced overtime against the Bills with 20 fourth-quarter points — but a complete game has been fleeting. Matthew Stafford has started to hit his stride after a slow start, completing 74.1% of his passes for 383 yards and three touchdowns against the Bills. He did not throw an interception for the first time this season. Puka Nacua had a career-high 17 receptions that went for 138 yards and a touchdown. Davante Adams had two TD receptions of his own. But the Rams’ kicking game proved costly. They signed Blake Grupe off the New York Jets’ practice squad. In 50 career NFL games over three seasons, mostly for the New Orleans Saints, Grupe has made 81.9% of his field goals. The Cardinals arrive on a four-game losing streak after a 45-21 loss to the Detroit Lions on Sunday. The next day, the Cardinals traded Marvin Harrison Jr. to Houston. Jacoby Brissett completed 61.7% of his passes for 292 yards and three touchdowns, but the Cardinals’ defense gave up 412 total yards, including 163 on the ground. The Lions put the game away with three second-half touchdowns. Arizona now heads back to the Los Angeles area, where they got their season off to what appeared to be a promising start with a 26-14 victory over the Los Angeles Chargers. Arizona gave up an average of 37 points over their last four games and former Rams assistant Mike LaFleur, in his first season coaching the Cardinals, might limit Jeremiyah Love this week because of an ankle injury. The Rams will be without left tackle Alaric Jackson, who was suspended for an altercation after Monday’s loss.
Los Angeles Chargers (0-5) at Kansas City Chiefs (4-0)
Sunday, 4:25 p.m. ET
FanDuel odds: Chiefs -7.5. Total 41.5.
Series Rewind: In their most recent meeting in Week 15 last season, the Chargers completed their first sweep of the Chiefs since 2013, eliminated Kansas City from playoff contention and left Patrick Mahomes with a torn left ACL.
Coming off a bye week, the Chiefs are looking for their fifth 5-0 start since head coach Andy Reid arrived in 2013. Including his 5-0 start with the Eagles in 2004, he can become the third coach in NFL history with six such starts (George Halas, Paul Brown). Mahomes is 10-4 against the Chargers with 28 touchdown passes and eight interceptions. Running back Kenneth Walker is off to a sizzling start with 621 scrimmage yards and six TDs in his first four games with Kansas City, which is playing at home for the first time in nearly a month (Sept. 20 win over the Colts). Travis Kelce needs six catches to pass Cris Carter (1,101) for sixth place in NFL history. Off to their worst start since 2003, the Chargers rank 30th with just 16.8 points per game. Justin Herbert has thrown at least one touchdown — and at least one pick — in every contest this season. Outside linebacker Khalil Mack has 10 sacks in 17 career games against the Chiefs.Buy Game Tickets
Buffalo Bills (4-1) at Las Vegas Raiders (3-2)
Sunday, 4:25 p.m. ET
Fan Duel odds: Bills -5.5. Total: 53.5.
Series Rewind: Buffalo has won the past three meetings and five of seven. The series dates back to 1960 when both teams were part of the American Football League. One forgettable meeting for the Raiders is when the Bills rolled to a 51-3 victory in the 1990 season AFC title game to reach the Super Bowl.
The Bills can move the ball at will and score often but they also can’t seem to slow down opposing offenses. That means a high-scoring affair could be on tap with Buffalo tied for the league lead in scoring at 32.8 points and Las Vegas checking in ninth at 26.4. The Bills stand 28th in scoring defense (28.2) and 30th in total defense (388.6). Monday’s 37-34 overtime road win over the Los Angeles Rams marked the third time this season Buffalo has scored more than 30 points and given up more than 30 in the same game. Running back James Cook III lost two fumbles – one in overtime with the Bills in field-goal range – and that takes the shine off him ranking third in the NFL with 532 rushing yards. Quarterback Josh Allen leads the NFL with eight rushing scores and he rushed for 121 yards against the Rams while passing the ball just 19 times. Receiver DJ Moore (shoulder) and defensive tackle Ed Oliver (knee) both look likely to miss their second consecutive games. The Raiders have dropped two straight contests and were whipped 45-17 by the host New England Patriots last week. Quarterback Kirk Cousins is playing well with 1,269 yards, 12 touchdowns and four interceptions while tight end Brock Bowers had eight receptions for 110 yards and one score against New England. Running back Ashton Jeanty had just 27 yards on 10 carries and has a paltry 3.3 average with 291 rushing yards. The Raiders entered the week tied for the NFL lead in turnover margin (+10).