Arizona Cardinals Los Angeles Chargers
Sunday, 4:25 p.m. ET
FanDuel odds: Chargers -9.5, Total 47.5
Series Rewind: Arizona won the last meeting between the teams, 17-15, in 2024. Overall, the Chargers lead the head-to-head series 11-5.
The Chargers are 6-1 in the season opener over the past seven seasons and are out to hit the ground running with new offensive coordinator Mike McDaniel promising plenty of running back Omarion Hampton. With their offensive line scrambled anew, the Chargers now have rookie Jake Slaughter at center and newcomer Kayode Awosika at left guard. They will try to get quarterback Justin Herbert back to the level he showed in 2021 when he passed for career highs of 5,014 yards and 38 touchdowns in his second NFL season. Keeping Herbert on two feet will be of the utmost importance after he was sacked a career-high 54 times in 2025. Herbert completed 66.4% of his passes last season for 3,727 yards and 26 touchdowns with 13 interceptions as the team went 11-6 before losing a wild-card playoff game to the New England Patriots. The Cardinals hired Mike LaFleur as head coach, plucking the younger brother of Packers head coach Matt LaFleur from Sean McVay’s coaching staff with the Rams. Jacoby Brissett gets another look as the QB1 with rookie No. 3 overall pick Jeremiyah Love (ankle) planning to get in on the action in Week 1. The Cardinals do have options at running back. Tyler Allgeier signed in free agency after scoring eight touchdowns with the Falcons last season and James Conner is back from a season-ending injury.
Washington Commanders at Philadelphia Eagles
Sunday, 4:25 p.m. ET
FanDuel odds: Eagles -5.5, Total 44.5
Series Rewind: Five of the last six regular-season meetings between the NFC East rivals have been decided by eight or fewer points. This is their earliest clash since Philadelphia’s 27-17 Week 1 win in 2020.
The two-time defending division champion Eagles have never lost a season opener (5-0 record) with Nick Sirianni as head coach and Jalen Hurts as the starting QB. Hurts has a new OC in Sean Mannion, a healthy Saquon Barkley in the backfield and one of the NFL’s best offensive lines. Hurts no longer has A.J. Brown, leaving DeVonta Smith as the undisputed WR1. Vic Fangio’s Philadelphia defense returns star tackles Jalen Carter and Jordan Davis and added OLB Jonathan Greenard, who was limited in practice this week after missing camp with a pec injury. The Commanders followed up a 12-5 effort in Year 1 under coach Dan Quinn with a 5-12 flop last season as injuries plagued second-year signal-caller Jayden Daniels. Daniels has 19 TDs (14 passing, five rushing) and just three picks in 12 career road starts. WR Terry McLaurin has 71 catches for 1,027 yards in 14 games against the Eagles. Washington’s new edge-rushing pairing of Odafe Oweh and K’Lavon Chaisson were both limited in practice this week.
Miami Dolphins at Las Vegas Raiders
Sunday, 4:25 p.m. ET
FanDuel odds: Raiders -3, Total 39.5
Series Rewind: The Dolphins have won four of the past five games in the series.
Malik Willis opens a season as QB1 for the first time in his career. Willis, who was drafted by the Titans and played for the Packers last season, has played in 22 career games but has only 155 pass attempts and eight turnovers (three interceptions, five fumbles lost). First-year coach Jeff Hafley was hired to replace Mike McDaniel. He was defensive coordinator in Green Bay and knows what he has in Willis, but there are many other variables in play with one of the league’s youngest rosters. Miami could begin the season with rookies listed as the starter or top backup at 10 of 22 positions. That includes two starting wide receivers, third-round picks Chris Bell and Caleb Douglas. The Dolphins released Tyreek Hill and traded Jaylen Waddle to the Broncos, and the QB1 spot opened for Willis after Tua Tagovailoa was released. One Miami skill-position mainstay, running back De’Von Achane, was retained and should power a potent running game in which Willis expects to be a factor. The Raiders resisted the urge to start No. 1 overall pick Fernando Mendoza. They’ll go with Kirk Cousins to open the season. He is in the top five among active quarterbacks in TD passes (298, third) and passing yards (44,700; fourth).
Green Bay Packers at Minnesota Vikings
Sunday, 4:25 p.m. ET
FanDuel odds: Vikings -1.5, Total 46.5
Series Rewind: The Vikings have won three of the last four regular-season meetings in this NFC North rivalry. Green Bay is 1-4 in its last five trips to Minneapolis and hasn’t won there in September since 2020.
Competing in arguably the NFL’s deepest division with the Lions and Bears, neither team wants to dig an early hole. The newest addition to this fierce rivalry is Vikings QB Kyler Murray, the 2019 No. 1 overall pick who went 0-2 against the Packers and 3-2-1 in season openers while with the Cardinals. Superstar receiver Justin Jefferson posted his sixth straight 1,000-yard campaign in 2025 but only scored twice. Head coach Kevin O’Connell’s offense also returns former Green Bay RB Aaron Jones, WR Jordan Addison and TE T.J. Hockenson. Safety Harrison Smith is back for Year 15 to captain the defense. The Packers reached the playoffs for the sixth time in seven seasons under coach Matt LaFleur in 2025 but are starting the 2026 season without RB Josh Jacobs (legal issues) and pass rusher Micah Parsons (left knee injury). QB Jordan Love, who has a losing record (4-5-1) as a starter in September, has a handful of healthy playmakers in wideouts Christian Watson, Jayden Reed, Matthew Golden and TE Tucker Kraft.
– Field Level Media