Tampa Bay Buccaneers (3-1) at Seattle Seahawks (3-1)
Sunday, 4:05 p.m. ET
FanDuel odds: Seahawks -3, Total 44.5
Series Rewind: Tampa Bay has lost its last two games at Seattle, last winning there in 2009. The Seahawks lead the series 9-6, but the Buccaneers have won five of the last seven.
Inside Edge intel: Seattle has allowed one rushing touchdown in the past 11 games. The Seahawks have prevented a rushing TD on 128 consecutive drives, best in the NFL.
Tampa Bay nearly pulled off its fourth straight comeback victory to begin the season, but dug itself too big a hole after falling behind 24-3 vs. Philadelphia last week, losing 31-25. QB Baker Mayfield has been exceptional on the road of late, throwing two-plus touchdowns in each of his last four road starts. However, he may be down a few weapons for this game at Seattle with Mike Evans (hamstring) still not practicing and RB Bucky Irving (237 rushing yards, 193 receiving yards) also sidelined in practice with foot/shoulder injuries suffered last week. The Buccaneers do possess the NFL’s longest active streak with 100-plus rushing yards in 13 consecutive games. The Seahawks have allowed less than 100 rushing yards in each of their past three games. Seattle is coming off a mini-bye after beating Arizona on a last-second field goal last Thursday. The Seahawks have won three straight games since losing their season opener. WR Jaxon Smith-Njigba is one of just two players with 90-plus scrimmage yards in all four games this season and RB Kenneth Walker has five carries for 15-plus yards. Seattle’s defense ranks sixth with 12 sacks, including six in the Arizona win. However, it could be a bit depleted with cornerback Devon Witherspoon (knee) and safety Julian Love (hamstring) each not practicing Wednesday or Thursday.
Tennessee Titans (0-4) at Arizona Cardinals (2-2)
Sunday, 4:05 p.m. ET
FanDuel odds: Cardinals -8.5, Total 41.5
Series Rewind: Kyler Murray threw four touchdown passes and rushed for a score in the most recent matchup, the Cardinals’ 38-13 win in Nashville in 2021.
Inside Edge intel: Arizona’s Trey McBride has been targeted more than any tight end in the NFL — 9.1 times per game — since the start of the 2024 season.
The Titans are one of three 0-4 teams in the NFL and have been outscored by a staggering 69 points. Rookie quarterback Cam Ward sharply criticized the team after Tennessee was outclassed 26-0 by the Houston Texans last week. The Titans had just 175 offensive yards and Ward set season lows for completion rate (38.5 percent) and passing yardage (108). It has been a bumpy start for the No. 1 overall pick. Ward is completing a league-worst 51.2 percent of his throws (among qualifiers) for 614 yards with two touchdowns and two interceptions. Arizona dropped consecutive games by four total points to NFC West rivals San Francisco and Seattle the past two weeks. The Cardinals overcame a 14-point deficit against the Seahawks before falling on a field goal as time expired. Cardinals receiver Marvin Harrison Jr. caught six passes for 66 yards and one TD in that contest but also had a ball roll off his hands into those of Seattle’s Ernest Jones IV for an interception. The Cardinals lost running back as Trey Benson (knee) and placed him on injured reserve after losing standout James Conner to a season-ending foot injury in the previous game. Either Michael Carter or Emari Demercado will start at RB on Sunday.
Detroit Lions (3-1) at Cincinnati Bengals (2-2)
Sunday, 4:25 p.m. ET
FanDuel odds: Lions -10.5, Total 48.5
Series Rewind: Cincinnati has won 10 of the past 11 games in the series.
Inside Edge intel: Lions WR Jameson Williams is averaging 8.0 yards per catch this season, third in the NFL. The Bengals are 29th in the NFL, allowing an average of 5.4 yards after catch this season.
Detroit is No. 1 in the NFL with 34.3 points per game as the Lions shrug off outside concern the offense might veer off the rails without coordinator Ben Johnson. QB Jared Goff leads the NFC with nine TD passes and has been pristine on the road with a completion percentage over 70 percent in nine of his last 10 road starts. The Bengals are standing by Jake Browning at quarterback, but he’s generated only one touchdown in eight quarters over the two starts since Joe Burrow’s toe injury. Browning is 3-1 in four career starts at home. Turnovers are breaking the Bengals’ backs — Browning has thrown a pick for every 10.67 completions — and holding off the Lions’ pass rush headed by Aidan Hutchinson (4.0 sacks this season) is highest priority. Without time to throw, Browning risks continuing to be a target of WR Ja’Marr Chase’s frustration. They’ve connected five times in each of Browning’s starts this season but for a grand total of 73 yards.
Washington Commanders (2-2) at Los Angeles Chargers (3-1)
Sunday, 4:25 p.m. ET
FanDuel odds: Chargers -2.5, Total 48.5
Series Rewind: Different millennium, different results. The Chargers were 0-6 vs. Washington in the 20th century but are 5-1 since 2001, the only loss coming in overtime in 2013. Norv Turner coached Washington (1994-2000) and the Chargers (2007-12).
Inside Edge intel: Since Jim Harbaugh was hired in Jan. 2024, the Chargers have 10 games with 120-plus rushing yards. Last week (161 rushing yards at Giants) was the first loss under Harbaugh in a game where the team rushing total was over 120.
It’s a California homecoming for Commanders quarterback Jayden Daniels, who grew up in San Bernardino and has been cleared to return after missing two games with a left knee injury. Washington managed a split in his absence with Marcus Mariota at the controls but will need Daniels at his best against a stingy Chargers defense that ranks third in the NFL, allowing 270.0 yards per game. The Washington D has been more generous, ranked 27th against the pass. That could be just the tonic Justin Herbert needs, as the L.A. QB has seen his completion percentage drop each week: 73.5 to 70.4 to 59.6 and down to 56.1 in last week’s humbling loss to the previously winless Giants. Both sides are rolling with rookie running backs, the Chargers with first-rounder Omarion Hampton (270 rushing yards, two TDs) and the Commanders with seventh-round surprise Jacory Croskey-Merritt (172 rush yards, two TDs).