Minnesota Vikings (2-0) at Tampa Bay Buccaneers (0-2)
Sunday, 4:05 p.m. ET
FanDuel odds: Vikings -1.5, Total 42.5
Series Rewind: Tampa Bay has won the last two games and eight of the last 10 against Minnesota. However, the Vikings hold a 33-24 edge in the all-time series.
Kyler Murray returns to Minnesota this week with the team in a great spot. Since he exited in the first quarter of the Vikings’ season opener vs. Green Bay, the team has won both of its first two games and is atop the NFC North. All-Pro wideout Justin Jefferson has 15 catches for 147 yards and two touchdowns in two games despite playing most of that time without Murray. Minnesota will also have starting running back Aaron Jones Sr. available after he missed Wednesday’s practice and his status was initially in doubt. Tampa Bay followed up a 33-27 road loss at Cincinnati in Week 1 with a surprising 23-19 home loss to Cleveland last week. Baker Mayfield, fresh off signing his three-year contract extension, has a pedestrian 86.6 passer rating and has thrown for 398 yards, one touchdown and one interception. The Buccaneers will be without a pair of rookies taken in the first two rounds of April’s draft in linebackers Rueben Bain Jr. (groin) and Josiah Trotter (shoulder).
Arizona Cardinals (1-1) at San Francisco 49ers (2-0)
Sunday, 4:25 p.m. ET
FanDuel odds: 49ers -8.5, Total 48.5
Series Rewind: The 49ers swept the Cardinals last season to improve head coach Kyle Shanahan’s career record against Arizona to 9-9.
Only Lions QB Jared Goff (25) has a longer active streak of consecutive games with a TD pass than Jacoby Brissett, who is going for 15 straight games with a scoring toss. Fans are clamoring for one of those passes to land in the hands of Marvin Harrison Jr. The 2025 first-round pick has only one catch this season, but Michael Wilson is a familiar villain for the San Francisco defense. Wilson set career highs with 15 receptions for 185 yards in the last meeting. 49ers QB Brock Purdy has 13 touchdowns (one rushing) in five career starts against the Cardinals and Arizona never enjoys seeing Christian McCaffrey coming. He has three touchdowns or more in three of the past four meetings. This is San Francisco’s first close-up with Cardinals first-round rookie RB Jeremiyah Love. The 49ers have allowed only 20 total points this season.
Las Vegas Raiders (2-0) at New Orleans Saints (1-1)
Sunday, 4:25 p.m. ET
FanDuel odds: Saints -3, Total 43.5
Series Rewind: The Raiders won the most recent meeting, 25-10 in New Orleans, in 2024. Las Vegas has won three of the past four games between the teams.
The Raiders finished in a four-way tie for the worst record in the league last season (3-14), and their reward for such a poor season — No. 1 overall pick Fernando Mendoza — hasn’t even been a factor. He has been an understudy to 15-year veteran Kirk Cousins, who is thriving in first-year head coach Klint Kubiak’s offense, throwing three touchdown passes in each of the first two games. New Orleans head coach Kellen Moore, a former quarterback, noted that he and Cousins entered the NFL the same season (2012) after being teammates in the Senior Bowl. Cousins’ experience is paying off for Las Vegas. The Saints are one of five teams that began the season with consecutive road games. Only they, the Browns and Packers managed to win a game while the Dolphins and the Commanders both started 0-2. But like the Raiders, the Saints are emphasizing that an encouraging start doesn’t mean much this early in the season. QB Tyler Shough leads the NFL in passing yards (662). New Orleans, however, is 28th in rushing (78 yards per game). The Saints are one failed two-point conversion in their opener away from being 2-0 despite facing early double-digit deficits in both games. They fell behind Detroit 21-0 before Shough led a comeback to reach overtime, where his two-point conversion pass went incomplete on the final play of a 31-30 loss. Last week, they fell behind the Ravens 14-3 before Shough led another comeback and sneaked one yard on fourth down for a late touchdown that produced a 24-17 victory.
Baltimore Ravens (1-1) at Dallas Cowboys (1-1) in Rio de Janeiro, Brazil
Sunday, 4:25 p.m. ET
FanDuel odds: Ravens -3.5, Total 52.5
Series Rewind: The Ravens have won six of seven meetings with the Cowboys.
With a win and a loss under their belts, the Cowboys and Ravens roll into Brazil with questions to answer. Dallas has been torched after a miserable performance got defensive coordinator Matt Eberflus fired in 2025. Christian Parker is still finding the right mix of personnel, and enters a rough week for experimenting. The Cowboys are allowing 173.5 rushing yards per game and their win over the Commanders might have turned out differently had Washington not lost quarterback Jayden Daniels to injury on the final play of the first half. Daniels was carving up the Cowboys with his feet; he had 69 rushing yards in the half. Derrick Henry is second in the league in rushing (212 yards) and QB Lamar Jackson is seventh in the NFL in total passing yards and is averaging a league-leading 10 yards per attempt. Jackson also has 74 yards rushing this season. Baltimore hasn’t been perfect, with injuries limiting what Jackson can do in the passing game. WR Zay Flowers had 150 yards in the first half of Week 1 but hasn’t played since because of a hamstring. Uncertain field conditions might give first-year head coach Jesse Minter pause about playing Flowers this week. The Cowboys can also go right at a Baltimore secondary that didn’t hold up well against the Saints in a home loss last week. Dak Prescott threw four TD passes Week 2.